3. Alessandro Gozzi

Alessandro Gozzi

Senior Researcher Tenured - Principal Investigator
Group Leader

Research Lines

Functional Neuroimaging

Center

cncs-unitn

About

After receiving a master degree in Biotechnology at the University of Verona (Italy) in 1998, I  joined the neuroscience centre of GlaxoSmithKline (GSK), a large research-based pharmaceutical company based in Verona (Italy) and Harlow (UK), where I pioneered the use of functional magnetic resonance imaging (MRI) to describe the neural substrates modulated by pharmacological agents, a line of research that I  also pursued to obtain a PhD degree in biomedical imaging with the University of Verona.

During my years at GSK I took on roles of increasing responsibility, and developed a strong background in MRI, image processing and analysis, as well as in the application of translational approaches to study neuropsychiatric brain disorders.

In 2010 I joined the Istituto Italiano di Tecnologia, where I lead the Functional Neuroimaging Laboratory. The lab is equipped with a 4-channel 7 Tesla MRI scanner for in vivo imaging. 

During my research activity, I have described the circuital substrates modulated by centrally-active agents in multiple areas of experimental neuroscience (e.g. schizophrenia, depression, drug addiction etc.) and identified functional and structural alterations in different rodent models of brain pathology. More recently, I have demonstrated the feasibility of using fMRI in combination with pharmaco-genetic silencing to dissect the circuital basis of complex behaviors, and demonstrated for the first time that the mouse brain contains distributed resting-state functional connectivity networks, including plausible homologues of the human default-mode (DMN) and salience networks.

My current research is primarily focused on the application of advanced MRI methods to investigate the large-scale neurofunctional architecture of the mouse brain, and describe its modulation by neurodevelopmental and pathological effectors. A major goal of my research is to probe the activity of functional network systems as a novel cross-species translational language that can be related to specific behaviours, cognitive processes and neuropathological traits.

 

Projects

My research focuses on the development and application of advanced MRI methods to describe large scale circuits in the mammalian brain and to understand the basis of functional disconnection in brain disorders.

Active research projects include

- description of the connectional architecture of the mouse brain using fMRI

- brain-wide mapping of neruomodulatory activity

- application of advanced functional MRI methods to investigate the basis of fucntional disconnectivity observed in developmental disorders 

In 2018 I have been awarded of Starting Grant from the European REseacrh Council (ERC) on the investigation of neural basis of functional disconnectivity

Graduate student training opportunities include studies at multiple levels across the areas of research described above, with a particular focus on image analysis and processing, and the development and validation of concurrent MRI/ optical and electro-physiological measurements.

Google Scholar Bibliometrics
http://scholar.google.it/citations?user=Giz31hsAAAAJ&hl=it&oi=ao

Selected Publications

Sforazzini F, Berterto A, Dodero L, David G, Galbusera A,  Scattoni ML, Pasqualetti M, Gozzi A*
Altered functional connectivity networks in acallosal and socially-impaired BTBR mice
(2014) Brain Structure & Function, In press

M Squillace, L Dodero, M Federici, S Migliarini, F Errico, F Napolitano, P Krashia, A Di Maio, A Galbusera, A Bifone, ML Scattoni, M Pasqualetti, NB Mercuri, A Usiello, A Gozzi*
Dysfunctional dopaminerig neurotransmission in asocial BTBR mice
(2014) Translational Psychiatry, 4(8) e427

Yang BZ, Paolicelli R, Sforazzini F, Weinhard L, Bolasco G, Pagani F, Vissosktsy A, Bifone A, Gozzi A, Ragozzino D, Gross C
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.
(2014) Nature Neuroscience, 17, 400-406


Sforazzini, F., Schwarz, A.J., Galbusera,A., Bifone,A., Gozzi, A*
Distributed BOLD and CBV-weighted resting-state networks in the mouse brain
(2013) Neuroimage, 87, 403-415

Dodero, L., Damiano, M., Galbusera, A. Bifone, A., Tsaftsaris, S.A., Scattoni, M.L., Gozzi, A*
Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism.
(2013) PLoS ONE, 8 (10), art. no. e76655








IIT Publications

  • 2019
  • Chelini G., Zerbi V., Cimino L., Grigoli A., Markicevic M., Libera F., Robbiati S., Gadler M., Bronzoni S., Miorelli S., Galbusera A.iit, Gozzi A.iit, Casarosa S., Provenzano G., Bozzi Y.
    DOI

    Aberrant somatosensory processing and connectivity in mice lacking engrailed-2

    Journal of Neuroscience, vol. 39, (no. 8), pp. 1525-1538
  • De Felice A., Pagani M.iit, Coletta L., Galbusera A.iit, Gozzi A.iit

    Acute and chronic intranasal oxytocin differentially affect brain functional connectivity

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
  • Pagani M.iit, Bertero A., De Felice A., Locarno A., Miseviciute I., Trakoshis S., Canella C., Supekar K., Menon V., Galbusera A.iit, Tonini R., Lombardo M.V., Pasqualetti M., Gozzi A.iit

    A mechanistic link between deficient synaptic pruning and functional hyper-connectivity in autism

    Annual Meeting of the Society for Neuroscience
  • Pagani M.iit, Bertero A., De Felice A., Supekar K., Trak S., Galbusera A.iit, Lombardo M., Menon V., Pasqualetti M., Gozzi A.iit

    A mechanistic link between deficient synaptic pruning and functional hyper-connectivity in autism

    Annual Meeting of the Organization for Human Brain Mapping
  • Pagani M.iit, Bertero A., Liska A., Galbusera A.iit, Sabbioni M., Barsotti N., Colenbier N., Marinazzo D., Scattoni M.L., Pasqualetti M., Gozzi A.iit

    Deletion of autism risk gene Shank3 disrupts prefrontal connectivity

    Journal of Neuroscience
  • Crimi A.iit, Giancardo L.iit, Sambataro F., Gozzi A.iit, Murino V.iit, Sona D.iit
    DOI

    MultiLink Analysis: Brain Network Comparison via Sparse Connectivity Analysis

    Scientific Reports, vol. 9, (no. 1)
  • Coletta L.iit, Pagani M.iit, Bernhardt B., Gozzi A.iit

    Network structure of the mouse brain connectome with voxel resolution

    International Society for Magnetic Resonance in Medicine (ISMRM), 27th meeting, 2019
  • Gutierrez-Barragan D.iit, Basson A.M., Panzeri S.iit, Gozzi A.iit

    Oscillatory brain states govern rsfMRI network dynamics in the mouse brain

    Organization for Human Brain Mapping
  • 2018
  • De Felice A.iit, Pagani M.iit, Galbusera A.iit, Gozzi A.iit

    Acute and Chronic intranasal oxytocin differentially affect brain functional connectivity

    10th FENS Forum of Neuroscience
  • Gutierrez-Barragan D.iit, Basson A.M., Panzeri S.iit, Gozzi A.iit

    Altered brain-wide neural dynamics in mouse models of autism

    Annual Meeting of the Society for Neuroscience 2018
  • Suetterlin P., Hurley S., Mohan C., Riegman K.L.H., Pagani M.iit, Caruso A., Ellegood J., Galbusera A.iit, Crespo-Enriquez I., Michetti C.iit, Yee Y., Ellingford R., Brock O., Delogu A., Francis-West P., Lerch J.P., Scattoni M.L., Gozzi A.iit, Fernandes C., Basson M.A.
    DOI

    Altered neocortical gene expression, brain overgrowth and functional over-connectivity in chd8 haploinsufficient mice

    Cerebral Cortex, vol. 28, (no. 6), pp. 2192-2206
  • Pagani M.iit, Liska A., Galbusera A.iit, Sabbioni M., Scattoni M.L., Gozzi A.iit

    Altered prefrontal functional connectivity and anatomy in mice lacking autism-associated gene Shank3

    International Society for Autism Research
  • Bertero A., Liska A., Parolisi R., Esteban M.M., Pagani M.iit, Gritti M., Pedrazzoli M., Galbusera A.iit, Sarica A., Cerasa A., Buffelli M., Tonini R., Buffo A., Gross C., Pasqualetti M., Gozzi A.iit

    Autism-associated 16p11.2 microdeletion impairs prefrontal functional connectivity in mouse and human

    International Society for Autism Research
  • Bertero A.iit, Liska A.iit, Pagani M.iit, Parolisi R., Masferrer M.E., Gritti M.iit, Pedrazzoli M.iit, Galbusera A.iit, Sarica A., Cerasa A., Buffelli A., Tonini R.iit, Buffo A., Gross C., Pasqualetti M.iit, Gozzi A.iit
    DOI

    Autism-associated 16p11.2 microdeletion impairs prefrontal functional connectivity in mouse and human

    Brain, vol. 141, (no. 7), pp. 2055-2065
  • Gutierrez-Barragan D.iit, Basson A.M., Panzeri S.iit, Gozzi A.iit

    Brain-wide mapping of fMRI network dynamics in the mouse brain

    Sixth Biennial Conference on Resting State and Brain Connectivity
  • Liska A.iit, Bertero A.iit, Gomolka R.iit, Sabbioni M., Galbusera A.iit, Barsotti N., Panzeri S.iit, Scattoni M.L., Pasqualetti M.iit, Gozzi A.iit
    DOI

    Homozygous loss of autism-risk gene cntnap2 results in reduced local and long-range prefrontal functional connectivity

    Cerebral Cortex, vol. 28, (no. 4), pp. 1141-1153
  • Gutierrez-Barragan D.iit, Basson A.M., Panzeri S.iit, Gozzi A.iit
    DOI

    Oscillatory brain states govern spontaneous fMRI network dynamics

    biorXiv
  • Pucilowska J., Vithayathil J., Pagani M.iit, Kelly C., Karlo J.C., Robol C.iit, Morella I., Gozzi A.iit, Brambilla R., Landreth G.E.
    DOI

    Pharmacological inhibition of ERK signaling rescues pathophysiology and behavioral phenotype associated with 16p11.2 chromosomal deletion in mice

    Journal of Neuroscience, vol. 38, (no. 30), pp. 6640-6652
  • Bifone A.iit, Gozzi A.iit, Cippitelli A., Matzeu A., Domi E., Li H., Scuppa G., Cannella N., Ubaldi M., Weiss F., Ciccocioppo R.

    phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats

    Addiction Biology
  • Cavaccini A.iit, Gritti M.iit, Giorgi A.iit, Locarno A.iit, Heck N., Migliarini S., Bertero A.iit, Mereu M., Margiani G., Trusel M.iit, Catelani T.iit, Marotta R.iit, De Luca M.A., Caboche J., Gozzi A.iit, Pasqualetti M.iit, Tonini R.iit
    DOI

    Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits

    Neuron, vol. 98, (no. 4), pp. 801-816.e7
  • Maddaloni G., Migliarini S., Napolitano F., Giorgi A., Nazzi S., Biasci D., De Felice A., Gritti M., Cavaccini A., Galbusera A.iit, Franceschi S., Lessi F., La Ferla M., Aretini P., Mazzanti C. M., Tonini R.iit, Gozzi A.iit, Usiello A., Pasqualetti M.
    DOI

    Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress

    Scientific Reports
  • Maddaloni G., Migliarini S., Napolitano F., Giorgi A., Nazzi S., Biasci D., De Felice A.iit, Gritti M., Cavaccini A., Galbusera A.iit, Franceschi S., Lessi F., Ferla M., Aretini P., Mazzanti CM., Tonini R., Gozzi A.iit, Usiello A., Pasqualetti M.
    DOI

    Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress.

    Scientific Reports
  • Awad P.N., Johnson-Venkatesh E., Markicevic M., Pagani M.iit, Centofante E., Zerbi V., Gozzi A.iit, Unemori H., Fagiolini M.

    Testing functional and structural connectivity in CDKL5 disorder as novel biomarker

    Annual Meeting for Society for Neuroscience
  • Zerbi V., Markicevic M., Pagani M.iit, Rudin M., Matteoli M., Fagiolini M., Bozzi Y., Provenzano G., Banerjee A., Ellegood J., Lerch J., Gozzi A.iit, Wenderoth N.

    The Autism Mouse Brain Connectome Project

    Annual Meeting for Society for Neuroscience
  • Pagani M.iit, Gutierrez-Barragan D.iit, Basson A.M., Panzeri S.iit, Gozzi A.iit

    Unweaving the spectrum: altered functional connectivity and brain-wide neural dynamics in mouse models of syndromic autism

    Gordon Research Conferences
  • 2017
  • Pagani M.iit, Galbusera A.iit, Gozzi A.iit

    Aberrant striatal anatomy and gray matter connectivity networks in mice lacking autism-associated gene CNTNAP2

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM),Honolulu
  • Sannino S.iit, Padula M.C., Manago F.iit, Schaer M., Schneider M., Armando M., Scariati E., Sloan-Bena F., Mereu M.iit, Pontillo M., Vicari S., Contarini G., Chiabrera C.iit, Pagani M.iit, Gozzi A.iit, Eliez S., Papaleo F.iit
    DOI

    Adolescence is the starting point of sex-dichotomous COMT genetic effects

    Translational Psychiatry, vol. 7, (no. 5)
  • Pagani M.iit, Robol C.iit, Gomolka R.iit, Liska A.iit, Galbusera A.iit, Aksiuto A.iit, Gozzi A.iit

    Altered default mode network organization and functional connectivity in mice lacking autism-associated gene Shank3

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM),Honolulu
  • Pagani M.iit, Bertero A., Sabbioni M., Robol C., Gomolka R., Liska A., Galbusera A.iit, Aksiuto A., Scattoni M. L., Pasqualetti M., Gozzi A.iit

    Altered prefrontal anatomy and functional connectivity in mice lacking autism- associated gene Shank3

    Annual Meeting of the Society for Neuroscience 2017
  • Gomez C.H.iit, Dodero L.iit, Gozzi A.iit, Murino V.iit, Sona D.iit
    DOI

    Atlas-free connectivity analysis driven by white matter structure

    Proceedings - International Symposium on Biomedical Imaging, pp. 89-92
  • Bertero A.iit, Liska A.iit, Parolisi R., Gritti M., Pedrazzoli M., David G.iit, Valetto G., Galbusera A.iit, Sarca E., Cerasa A., Buffelli M., Tonini R.iit, Buffo A., Pasqualetti M., Gozzi A.iit

    Autism associated 16p11.2 microdeletion impacts prefrontal connectivity in humans and mice

    Annual Meeting of the Society for Neuroscience 2017
  • Giorgi A.iit, Migliarini S., Galbusera A.iit, Maddaloni G., Mereu M., Margiani G., Gritti M.iit, Landi S., Trovato F., Bertozzi S.M.iit, Armirotti A.iit, Ratto G.M., De Luca M.A., Tonini R.iit, Gozzi A.iit, Pasqualetti M.iit
    DOI

    Brain-wide Mapping of Endogenous Serotonergic Transmission via Chemogenetic fMRI

    Cell Reports, vol. 21, (no. 4), pp. 910-918
  • Gutierrez-Barragan D.iit, Panzeri S.iit, Gozzi A.iit

    Brainwide mapping of spontaneous network dynamics in the mouse brain

    Annual Meeting of the Society for Neuroscience 2017
  • Vega-Pons S.iit, Olivetti E., Avesani P., Dodero L.iit, Gozzi A.iit, Bifone A.iit
    DOI

    Differential effects of brain disorders on structural and functional connectivity

    Frontiers in Neuroscience, vol. 10, (no. JAN)
  • Suetterlin P., Hurley S., Mohan C., Riegman K. L. H., Caruso A., Pagani M.iit, Ellegood J., Galbusera A.iit, Crespo-Enriquez I., Michetti C., Ellingford R., Brock O., Delogu A., FrancisWest P., Lerch J. P., Scattoni M. L., Gozzi A.iit, Fernandes C., Basson A.

    Distinctive behavioural anomalies, structural brain phenotypes and cortical hyper-connectivity in Chd8-deficient mice

    biorXiv
  • Gutierrez-Barragan D.iit, Panzeri S.iit, Gozzi A.iit

    Dynamic reconfiguration of spontaneous network activity in the mouse brain

    Brain Dynamics at multiple scales
  • Zhang D., Zhu D., Bifone A.iit, Gozzi A.iit, Capuani S., Palombo M.

    Efficient Parametric Imaging with GPU Computing

    61th Biophysical Society Annual Meeting
  • Bellistri E.iit, Pisanello M.iit, Pisano F.iit, Galbusera A.iit, Maglie E.iit, Vecchia D., Sabatini B. L., Fellin T.iit, Gozzi A.iit, De Vittorio M.iit, Pisanello F.iit

    Heat delivered into the brain with tapered optical fibers

    4TH INTERNATIONAL WORKSHOP ON TECHNOLOGIES FOR OPTOGENETICS AND NEUROPHOTONICS
  • Galbusera A.iit, De Felice A.iit, Girardi S., Bassetto G., Maschietto M., Nishimori K., Chini B., Papaleo F.iit, Vassanelli S., Gozzi A.iit
    DOI

    Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates

    Neuropsychopharmacology, vol. 42, (no. 7), pp. 1420-1434
  • Canella C.iit, Liska A.iit, Piretti V.iit, Galbusera A.iit, Schwarz A., Gozzi A.iit

    Muscarinic receptor agonism prevents functional connectivity aberrancies produced by the NMDAR antagonist phencyclidine (PCP)

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM),Honolulu
  • Pagani M.iit, Pucilowska J., Robol C., Vithayathil J., Kelly C., Karlo J. C., Brambilla R., Landreth G. E., Gozzi A.iit

    Pharmacological Inhibition of ERK Pathway Rescues Morpho-Anatomical Aberrancies Associated with 16p11.2 Chromosomal Deletion

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM),Honolulu
  • Schrantee A., Tremoleda J.L., Wylezinska-Arridge M., Bouet V., Hesseling P., Meerhoff G.F., De Bruin K.M., Koeleman J., Freret T., Boulouard M., Desfosses E., Galineau L., Gozzi A.iit, Dauphin F., Gsell W., Booij J., Lucassen P.J., Reneman L.
    DOI

    Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate

    PLoS ONE, vol. 12, (no. 2)
  • Maddaloni G., Migliarini S., Napolitano F., Giorgi A., Biasci D., De Felice A., Galbusera A.iit, Franceschi S., Lessi F., La Ferla M., Aretini P., Mazzanti C.M., Gozzi A.iit, Usiello A., Pasqualetti M.
    DOI

    Serotonin Buffers Hippocampal Neuroplasticity And Emotional Behavior

    biorXiv
  • Michetti C.iit, Caruso A., Pagani M.iit, Sabbioni M., Medrihan L.iit, David G.iit, Galbusera A.iit, Morini M.iit, Gozzi A.iit, Benfenati F.iit, Scattoni M.L.
    DOI

    The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype

    Cerebral Cortex, vol. 27, (no. 10), pp. 5014-5023
  • 2016
  • Sforazzini F.iit, Bertero A.iit, Dodero L.iit, David G.iit, Galbusera A.iit, Scattoni M.L., Pasqualetti M.iit, Gozzi A.iit
    DOI

    Altered functional connectivity networks in acallosal and socially impaired BTBR mice

    Brain Structure and Function, vol. 221, (no. 2), pp. 941-954
  • Pagani M.iit, Damiano M., Galbusera A.iit, Tsaftaris S. A., Gozzi A.iit

    An automated pipeline for mouse brain morphometric MRI

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Liska A.iit, Gozzi A.iit
    DOI

    Can mouse imaging studies bring order to autism connectivity chaos?

    Frontiers in Neuroscience, vol. 10, (no. NOV)
  • Bertero A.iit, David G.iit, Liska A.iit, Galbusera A.iit, Pasqualetti M.iit, Gozzi A.iit

    Default-mode network hypo-connectivity in a mouse model of human chromosome 16p11.2 microdeletion

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM),Honolulu
  • Bertero A., Pagani M.iit, David G., Liska A., Galbusera A.iit, Pasqualetti M., Gozzi A.iit

    Default‐mode network hypoconnectivity in a mouse model of human chromosome 16p11.2 microdeletion

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Lassi G.iit, Priano L., Maggi S.iit, Garcia-Garcia C.iit, Balzani E.iit, El-Assawy N., Pagani M.iit, Tinarelli F.iit, Giardino D., Mauro A., Peters J., Gozzi A.iit, Grugni G., Tucci V.iit
    DOI

    Deletion of the Snor D116/S no RD116 alters sleep in mice and patients with Prader-Willi syndrome

    Sleep, vol. 39, (no. 3), pp. 637-644
  • Nasseef Md. T., Liska A., Barragan D. G., Pagani M.iit, Panzeri S.iit, Gozzi A.iit

    Directed information flow in fMRI connectivity

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Nasseef T., Liska A., Gutierrez-Barragan D.iit, Pagani M.iit, Panzeri S., Gozzi A.iit

    Directed information flow in fMRI connectivity networks

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Nasseef T.iit, Liska A.iit, Gutierrez Barragan D.iit, Pagani M.iit, Panzeri S.iit, Gozzi A.iit

    Directed information flow in fMRI connectivity networks

    ISMRM Italian Chapter
  • Pesoli M., Cutuli D., Pagani M.iit, Caporali P., Galbusera A.iit, Laricchiuta D., Foti F., Neri C., Spalletta G., Caltagirone C., Petrosini L., Gozzi A.iit

    Effects of omega-3 fatty acid supplementation on cognitive functions and neural substrates: a voxel-based morphometry study in aged mice

    10th FENS Forum of Neuroscience 2016
  • Cutuli D., Pagani M.iit, Caporali P., Galbusera A.iit, Laricchiuta D., Foti F., Neri C., Spalletta G., Caltagirone C., Petrosini L., Gozzi A.iit
    DOI

    Effects of omega-3 fatty acid supplementation on cognitive functions and neural substrates: A voxel-based morphometry study in aged mice

    Frontiers in Aging Neuroscience, vol. 8, (no. MAR)
  • Pagani M.iit, Bifone A.iit, Gozzi A.iit

    Gray matter networks in the mouse brain

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Pagani M.iit, Bifone A.iit, Gozzi A.iit

    Grey matter networks in the mouse brain

    International Society for Magnetic Resonance in Medicine (ISMRM), 24th meeting, Singapore, May 2016
  • Bardella G., Bifone A.iit, Gabrielli A., Gozzi A.iit, Squartini T.
    DOI

    Hierarchical organization of functional connectivity in the mouse brain: A complex network approach

    Scientific Reports, vol. 6
  • Gutierrez Barragan D.iit, Nasseef T.iit, Liska A.iit, Panzeri S.iit, Gozzi A.iit

    Intrinsic directional connectivity in large-scale functional networks of the mouse brain

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Singapore
  • Gozzi A.iit, Schwarz A.
    DOI

    Large-scale functional connectivity networks in the rodent brain

    NeuroImage, vol. 127, pp. 469-509
  • Gozzi A.iit, Schwarz A.J.
    DOI

    Large-scale functional connectivity networks in the rodent brain

    NeuroImage, vol. 127, pp. 496-509
  • Pagani M.iit, Damiano M.iit, Galbusera A.iit, Tsaftaris S.A., Gozzi A.iit
    DOI

    Semi-automated registration-based anatomical labelling, voxel based morphometry and cortical thickness mapping of the mouse brain

    Journal of Neuroscience Methods, vol. 267, pp. 62-73
  • Pagani M.iit, Bifone A.iit, Gozzi A.iit
    DOI

    Structural covariance networks in the mouse brain

    NeuroImage, vol. 129, pp. 55-63
  • Pucilowska J., Kelly C., Karlo J., Gozzi A.iit, Brambilla R., Landreth G. E.

    Treatment with novel ERK inhibitor rescues ASD pathophysiology in 16p11.2 deletion mouse model

    SfN
  • 2015
  • Errico F., D'Argenio V., Sforazzini F.iit, Iasevoli F., Squillace M., Guerri G., Napolitano F., Angrisano T., Di Maio A., Keller S., Vitucci D., Galbusera A.iit, Chiariotti L., Bertolino A., De Bartolomeis A., Salvatore F., Gozzi A.iit, Usiello A.
    DOI

    A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice

    Translational Psychiatry, vol. 5, (no. 2)
  • Dodero L.iit, Vascon S.iit, Murino V.iit, Bifone A.iit, Gozzi A.iit, Sona D.iit
    DOI

    Automated multi-subject fiber clustering of mouse brain using dominant sets

    Frontiers in Neuroinformatics, vol. 8, (no. JAN)
  • Michetti C., Morini M., Caruso A., Sabbioni M., Pagani M.iit, Gergely D., Blesa M., Gozzi A.iit, Benfenati F.iit, Scattoni M.L.

    Behavioural and neuroanatomical characterisation of synapsin-II mouse.

    65esimo Congresso Nazionale della Società Italiana di Fisiologia
  • Sannino S.iit, Gozzi A.iit, Cerasa A., Piras F., Scheggia D.iit, Manago F.iit, Damiano M.iit, Galbusera A.iit, Erickson L.C., De Pietri Tonelli D.iit, Bifone A.iit, Tsaftaris S.A., Caltagirone C., Weinberger D.R., Spalletta G., Papaleo F.iit
    DOI

    COMT genetic reduction produces sexually divergent effects on cortical anatomy and working memory in mice and humans

    Cerebral Cortex, vol. 25, (no. 9), pp. 2529-2541
  • Nasseef T.iit, Liska A.iit, Panzeri S.iit, Gozzi A.iit

    Directed functional connectivity mapping in the mouse brain

    International Society for Magnetic Resonance in Medicine (ISMRM), 24th meeting, Singapore, May 2016
  • Bertero A.iit, Gergely D., Liska A., Galbusera A.iit, Pasqualetti M., Gozzi A.iit

    Frontal hypoconnectivity in the 16p11.2 microdeletion autism model

    Society of Neuroscience
  • Liska A.iit, Galbusera A.iit, Schwarz A.J., Gozzi A.iit
    DOI

    Functional connectivity hubs of the mouse brain

    NeuroImage, vol. 115, pp. 281-291
  • Minervini M., Rusu C., Damiano M.iit, Tucci V.iit, Bifone A.iit, Gozzi A.iit, Tsaftaris S.A.
    DOI

    Large-scale analysis of neuroimaging data on commercial clouds with content-aware resource allocation strategies

    International Journal of High Performance Computing Applications, vol. 29, (no. 4), pp. 473-488
  • Nasseef T.iit, Liska A.iit, Panzeri S.iit, Gozzi A.iit

    MAPPING EFFECTIVE CONNECTIVITY IN THE MOUSE BRAIN USING GRANGER CAUSALITY

    Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), toronto
  • Pagani M.iit, Bifone A.iit, Gozzi A.iit

    Networks of anatomical covariance of the mouse brain

    European Society for Magnetic Resonance in Medicine and Biology
  • Pagani M.iit, Cutuli D., Liska A., Caporali P., Laricchiuta D., Foti F., Neri C., Petrosini L., Gozzi A.iit

    Neural and cognitive substrates of omega-3 supplementation: a VBM study in aged mice.

    ISMRM Italian Chapter
  • Liska A.iit, Galbusera A.iit, Schwarz A., Gozzi A.iit

    Voxel-scale mapping of the mouse brain functional connectome

    International Society for Magnetic Resonance in Medicine(ISMRM), 23rd meeting, Toronto, Canada, May 2015
  • 2014
  • Di Giorgio A., Errico F., Fazio L., Squillace M., Vitucci D., Trizio S., D'Ambrosio E., Galbusera A.iit, Piccinin S., Mango D., Gozzi A.iit, Nisticò R., Blasi G., Bertolino A., Usiello A.

    D-Aspartate Levels and Related Genetic Variation are Associated with Prefrontal Phenotypes: A Translational Study From Rodents to Humans

  • Zhan Y., Paolicelli R.C., Sforazzini F.iit, Weinhard L., Bolasco G., Pagani F., Vyssotski A.L., Bifone A.iit, Gozzi A.iit, Ragozzino D., Gross C.T.
    DOI

    Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

    Nature Neuroscience, vol. 17, (no. 3), pp. 400-406
  • Sforazzini F.iit, Schwarz A.J., Galbusera A.iit, Bifone A.iit, Gozzi A.iit
    DOI

    Distributed BOLD and CBV-weighted resting-state networks in the mouse brain

    NeuroImage, vol. 87, pp. 403-415
  • Tucci V.iit, Kleefstra T., Hardy A., Heise I., Maggi S.iit, Willemsen M.H., Hilton H., Esapa C., Simon M., Buenavista M.-T., McGuffin L.J., Vizor L., Dodero L.iit, Tsaftaris S.iit, Romero R., Nillesen W.N., Vissers L.E.L.M., Kempers M.J., Vulto-van Silfhout A.T., Iqbal Z., Orlando M.iit, Maccione A.iit, Lassi G.iit, Farisello P.iit, Contestabile A.iit, Tinarelli F.iit, Nieus T.iit, Raimondi A.iit, Greco B.iit, Cantatore D.iit, Gasparini L.iit, Berdondini L.iit, Bifone A.iit, Gozzi A.iit, Wells S., Nolan P.M.
    DOI

    Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

    Journal of Clinical Investigation, vol. 124, (no. 4), pp. 1468-1482
  • Squillace M.iit, Dodero L.iit, Federici M., Migliarini S., Errico F., Napolitano F., Krashia P., Di Maio A., Galbusera A.iit, Bifone A.iit, Scattoni M.L., Pasqualetti M., Mercuri N.B., Usiello A., Gozzi A.iit
    DOI

    Dysfunctional dopaminergic neurotransmission in asocial BTBR mice

    Translational Psychiatry, vol. 4
  • Errico F., Nistico R., Di Giorgio A., Squillace M., Vitucci D., Galbusera A.iit, Piccinin S., Mango D., Fazio L., Middei S., Trizio S., Mercuri N.B., Teule M.A., Centonze D., Gozzi A.iit, Blasi G., Bertolino A., Usiello A.
    DOI

    Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals

    Translational Psychiatry, vol. 4
  • Dodero L.iit, Gozzi A.iit, Liska A.iit, Murino V.iit, Sona D.iit
    DOI

    Group-wise functional community detection through joint Laplacian diagonalization

    Lecture Notes in Computer Science, vol. 8674 LNCS, (no. PART 2), pp. 708-715
  • Galbusera A.iit, Bifone A.iit, Gozzi A.iit

    Intransal administration of neuroactive peptides elicits robust fMRI responses in the mouse brain

    23rd Annual Meeting European Society for Magnetic Resonance in Medicine and Biology, Milan, May 2014
  • Nicolini C.iit, Liska A.iit, Sforazzini F.iit, Galbusera A.iit, Bifone A.iit, Gozzi A.iit

    Modular organization of mouse brain functional connectivity

    23rd Annual Meeting European Society for Magnetic Resonance in Medicine and Biology, Milan, May 2014
  • Boni A.iit, Ceratti D., Antonelli A., Sfara C., Magnani M., Manuali E., Salamida S., Gozzi A.iit, Bifone A.iit
    DOI

    USPIO-loaded red blood cells as a biomimetic MR contrast agent: A relaxometric study

    Contrast Media and Molecular Imaging, vol. 9, (no. 3), pp. 229-236
  • 2013
  • Dodero L., Vascon S., Giancardo L., Gozzi A.iit, Sona D.iit, Murino V.iit
    DOI

    Automatic White Matter Fiber Clustering Using Dominant Sets

    Proceedings - 2013 3rd International Workshop on Pattern Recognition in Neuroimaging, PRNI 2013
  • Gozzi A.iit, Lepore S., Vicentini E., Merlo-Pich E., Bifone A.iit
    DOI

    Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: A fMRI study in the rat with the pharmacological stressor yohimbine

    Neuropsychopharmacology, vol. 38, (no. 11), pp. 2120-2130
  • Ciofani G.iit, Boni A.iit, Calucci L., Forte C., Gozzi A.iit, Mazzolai B.iit, Mattoli V.iit
    DOI

    Gd-doped BNNTs as T2-weighted MRI contrast agents

    Nanotechnology, vol. 24, (no. 31)
  • Cervo L., Di Clemente A., Orru A., Moro F., Cassina C., Pich E.M., Corsi M., Gozzi A.iit, Bifone A.iit
    DOI

    Inhibition of glycine transporter-1 reduces cue-induced nicotine-seeking, but does not promote extinction of conditioned nicotine cue responding in the rat

    Addiction Biology, vol. 18, (no. 5), pp. 800-811
  • Dodero L.iit, Damiano M.iit, Galbusera A.iit, Bifone A.iit, Tsaftsaris S.A., Scattoni M.L., Gozzi A.iit
    DOI

    Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism

    PLoS ONE, vol. 8, (no. 10)
  • Gozzi A.iit, Agosta F., Massi M., Ciccocioppo R., Bifone A.iit
    DOI

    Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction

    NeuroImage, vol. 69, pp. 112-119
  • Tramacere F.iit, Beccai L.iit, Kuba M., Gozzi A.iit, Bifone A.iit, Mazzolai B.iit
    DOI

    The Morphology and Adhesion Mechanism of Octopus vulgaris Suckers

    PLoS ONE, vol. 8, (no. 6)
  • 2012
  • Gozzi A.iit, Jain A., Giovannelli A., Bertollini C., Crestan V., Schwarz A., Tsetsenis T., Ragozzino D., Gross C., Bifone A.iit
    DOI

    A Neural Switch for Active and Passive Fear

    Neuron, vol. 73, (no. 4)
  • Ferrari L., Turrini G., Crestan V., Bertani S., Cristofori P., Bifone A.iit, Gozzi A.iit
    DOI

    A robust experimental protocol for pharmacological fMRI in rats and mice

    Journal of Neuroscience Methods, vol. 204, (no. 1), pp. 9-18
  • Giancardo L.iit, Sona D.iit, Gozzi A.iit, Bifone A.iit, Murino V.iit, Migliarini S., Pacini G., Pelosi B., Pasqualetti M.
    DOI

    Automatic tractography analysis through sparse networks in case-control studies

    Proceedings - 2012 2nd International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012, pp. 77-80
  • Wellman P.J., Clifford P.S., Rodriguez J.A., Hughes S., Di Francesco C., Melotto S., Tessari M., Corsi M., Bifone A.iit, Gozzi A.iit
    DOI

    Brain reinforcement system function is ghrelin dependent: Studies in the rat using pharmacological fMRI and intracranial self-stimulation

    Addiction Biology, vol. 17, (no. 5), pp. 908-919
  • Gozzi A.iit, Colavito V., Seke Etet P.F., Montanari D., Fiorini S., Tambalo S., Bifone A.iit, Zucconi G.G., Bentivoglio M.
    DOI

    Modulation of fronto-cortical activity by modafinil: A functional imaging and Fos study in the rat

    Neuropsychopharmacology, vol. 37, (no. 3), pp. 822-837
  • Minervini M., Damiano M.iit, Tucci V.iit, Bifone A.iit, Gozzi A.iit, Tsaftaris S.A.iit
    DOI

    Mouse neuroimaging phenotyping in the cloud

    2012 3rd International Conference on Image Processing Theory, Tools and Applications, IPTA 2012, pp. 55-60
  • Bifone A.iit, Gozzi A.iit
    DOI

    Neuromapping techniques in drug discovery: Pharmacological MRI for the assessment of novel antipsychotics

    Expert Opinion on Drug Discovery, vol. 7, (no. 11), pp. 1071-1082
  • Schwarz A.J., Gozzi A.iit, Chessa A., Bifone A.iit
    DOI

    Voxel scale complex networks of functional connectivity in the rat brain: Neurochemical state dependence of global and local topological properties

    Computational and Mathematical Methods in Medicine, vol. 2012
  • 2011
  • Bifone A.iit, Gozzi A.iit
    DOI

    Functional and pharmacological MRI in understanding brain function at a systems level

    Current Topics in Behavioral Neurosciences, vol. 7, (no. 1), pp. 323-357
  • Gozzi A.iit, Turrini G., Piccoli L., Massagrande M., Amantini D., Antolini M., Martinelli P., Cesari N., Montanari D., Tessari M., Corsi M., Bifone A.iit
    DOI

    Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists

    PLoS ONE, vol. 6, (no. 1)
  • Gozzi A.iit, Tessari M., Dacome L., Agosta F., Lepore S., Lanzoni A., Cristofori P., Pich E.M., Corsi M., Bifone A.iit
    DOI

    Neuroimaging evidence of altered fronto-cortical and striatal function after prolonged cocaine self-administration in the rat

    Neuropsychopharmacology, vol. 36, (no. 12), pp. 2431-2440
  • Large C.H., Bison S., Sartori I., Read K.D., Gozzi A.iit, Quarta D., Antolini M., Hollands E., Gill C.H., Gunthorpe M.J., Idris N., Neill J.C., Alvaro G.S.
    DOI

    The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: Potential for novel treatments for schizophrenia

    Journal of Pharmacology and Experimental Therapeutics, vol. 338, (no. 1), pp. 100-113
  • 2010
  • Gozzi A.iit, Jain A., Giovanelli A., Bertollini C., Crestan V., Schwarz A.J., Tsetsenis T., Ragozzino D., Gross C.T., Bifone A.iit
    DOI

    A neural switch for active and passive fear

    Neuron, vol. 67, (no. 4), pp. 656-666
  • Gozzi A., Crestan V., Turrini G., Clemens M., Bifone A.
    DOI

    Antagonism at serotonin 5-HT2A receptors modulates functional activity of frontohippocampal circuit

    Psychopharmacology, vol. 209, (no. 1), pp. 37-50
  • Ferrari L., Crestan V., Sabattini G., Vinco F., Fontana S., Gozzi A.
    DOI

    Brain penetration of local anaesthetics in the rat: Implications for experimental neuroscience

    Journal of Neuroscience Methods, vol. 186, (no. 2), pp. 143-149
  • Bifone A.iit, Gozzi A.iit, Schwarz A.J.
    DOI

    Functional connectivity in the rat brain: A complex network approach

    Magnetic Resonance Imaging, vol. 28, (no. 8), pp. 1200-1209
  • Gozzi A.iit, Bifone A.iit

    Modulation of the glutamatergic system: from rat to human

    British Association for Pyshcopharmacology, Summer meeting 2010, Harrogate, UK, vol. 24, (no. 3)
  • Gozzi A.iit

    Probing brain function with pharmacological MRI: application to psychiatric drug research

    CINP International congress, June 2010, Hong-Kong
  • 2009
  • Schwarz A.J., Gozzi A., Bifone A.
    DOI

    Community structure in networks of functional connectivity: Resolving functional organization in the rat brain with pharmacological MRI

    NeuroImage, vol. 47, (no. 1), pp. 302-311
  • 2008
  • Schwarz A.J., Gozzi A., Bifone A.
    DOI

    Community structure and modularity in networks of correlated brain activity

    Magnetic Resonance Imaging, vol. 26, (no. 7), pp. 914-920
  • Gozzi A., Large C.H., Schwarz A., Bertani S., Crestan V., Bifone A.
    DOI

    Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine

    Neuropsychopharmacology, vol. 33, (no. 7), pp. 1690-1703
  • Gozzi A., Schwarz A., Crestan V., Bifone A.
    DOI

    Drug-anaesthetic interaction in phMRI: the case of the psychotomimetic agent phencyclidine

    Magnetic Resonance Imaging, vol. 26, (no. 7), pp. 999-1006
  • Gozzi A., Herdon H., Schwarz A., Bertani S., Crestan V., Turrini G., Bifone A.
    DOI

    Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat

    Psychopharmacology, vol. 201, (no. 2), pp. 273-284
  • 2007
  • Micheli F., Bonanomi G., Blaney F.E., Braggio S., Capelli A.M., Checchia A., Curcuruto O., Damiani F., Di Fabio R., Donati D., Gentile G., Gribble A., Hamprecht D., Tedesco G., Terreni S., Tarsi L., Lightfoot A., Stemp G., MacDonald G., Smith A., Pecoraro M., Petrone M., Perini O., Piner J., Rossi T., Worby A., Pilla M., Valerio E., Griffante C., Mugnaini M., Wood M., Scott C., Andreoli M., Lacroix L., Schwarz A., Gozzi A., Bifone A., Ashby Jr. C.R., Hagan J.J., Heidbreder C.
    DOI

    1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines: A series of potent and selective dopamine D3 receptor antagonists

    Journal of Medicinal Chemistry, vol. 50, (no. 21), pp. 5076-5089
  • Gozzi A., Ceolin L., Schwarz A., Reese T., Bertani S., Crestan V., Bifone A.
    DOI

    A multimodality investigation of cerebral hemodynamics and autoregulation in pharmacological MRI

    Magnetic Resonance Imaging, vol. 25, (no. 6), pp. 826-833
  • Ceolin L., Schwarz A.J., Gozzi A., Reese T., Bifone A.
    DOI

    Effects of cocaine on blood flow and oxygen metabolism in the rat brain: implications for phMRI

    Magnetic Resonance Imaging, vol. 25, (no. 6), pp. 795-800
  • Schwarz A.J., Gozzi A., Reese T., Bifone A.
    DOI

    Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d-amphetamine

    Magnetic Resonance in Medicine, vol. 57, (no. 4), pp. 704-713
  • Schwarz A.J., Gozzi A., Reese T., Bifone A.
    DOI

    In vivo mapping of functional connectivity in neurotransmitter systems using pharmacological MRI

    NeuroImage, vol. 34, (no. 4), pp. 1627-1636
  • Schwarz A.J., Gozzi A., Reese T., Heidbreder C.A., Bifone A.
    DOI

    Pharmacological modulation of functional connectivity: the correlation structure underlying the phMRI response to d-amphetamine modified by selective dopamine D3 receptor antagonist SB277011A

    Magnetic Resonance Imaging, vol. 25, (no. 6), pp. 811-820
  • Schwarz A.J., Whitcher B., Gozzi A., Reese T., Bifone A.
    DOI

    Study-level wavelet cluster analysis and data-driven signal models in pharmacological MRI

    Journal of Neuroscience Methods, vol. 159, (no. 2), pp. 346-360
  • 2006
  • Schwarz A.J., Danckaert A., Reese T., Gozzi A., Paxinos G., Watson C., Merlo-Pich E.V., Bifone A.
    DOI

    A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: Application to pharmacological MRI

    NeuroImage, vol. 32, (no. 2), pp. 538-550
  • Gozzi A., Schwarz A., Reese T., Bertani S., Crestan V., Bifone A.
    DOI

    Region-specific effects of nicotine on brain activity: A pharmacological MRI study in the drug-näve rat

    Neuropsychopharmacology, vol. 31, (no. 8), pp. 1690-1703
  • 2005
  • Gozzi A., Schwarz A.J., Reese T., Crestan V., Bertani S., Turrini G., Corsi M., Bifone A.
    DOI

    Functional magnetic resonance mapping of intracerebroventricular infusion of a neuroactive peptide in the anaesthetised rat

    Journal of Neuroscience Methods, vol. 142, (no. 1), pp. 115-124
  • 2004
  • Schwarz A.J., Zocchi A., Reese T., Gozzi A., Garzotti M., Varnier G., Curcuruto O., Sartori I., Girlanda E., Biscaro B., Crestan V., Bertani S., Heidbreder C., Bifone A.
    DOI

    Concurrent pharmacological MRI and in situ microdialysis of cocaine reveal a complex relationship between the central hemodynamic response and local dopamine concentration

    NeuroImage, vol. 23, (no. 1), pp. 296-304
  • Schwarz A., Gozzi A., Reese T., Bertani S., Crestan V., Hagan J., Heidbreder C., Bifone A.
    DOI

    Selective dopamine D3 receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain

    Synapse, vol. 54, (no. 1), pp. 1-10
  • 2003
  • Schwarz A.J., Reese T., Gozzi A., Bifone A.
    DOI

    Functional MRI using intravascular contrast agents: Detrending of the relative cerebrovascular (rCBV) time course

    Magnetic Resonance Imaging, vol. 21, (no. 10), pp. 1191-1200

Awards

ERC Starting Grant, Neural basis of fucntional disconnectivity in brain disorders - DisConn, 2019-2024

NARSAD Indpendent Investigator Grant 2017

Simmons Foundation for Autism Research (SFARI) explorer award (2016)

Simmons Foundation for Autism Research (SFARI) explorer award (2014)

GlaxoSmithKline Exceptional Science Award (2006)

GlaxoSmithKline Scinovation Award (2007 and 2009)