Alessia De Felice

Post Doc
Post Doc

About

EDUCATION

2011-2014  Ph.D in Pharmacology and Toxicology Sapienza, University of Rome. Supervised by Dr. Gemma Calamandrei, Section of Neurotoxicology And Neuroendocrinology, Italian Institute of Health, Rome; Prof. Silvana Gaetani, Dept. of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza, University of Rome. Thesis title: “Understanding the role of environmental contaminants in the etiology of neurodevelopmental disorders: Neurobehavioral and neuroendocrine effects of the organophosphate insecticide chlorpyrifos in mouse models”

2009-2011 Master Degree in Neurobiology, 110/110 summa cum laude, Sapienza, University of Rome. Supervised by Dr. Gemma Calamandrei, Sectionf of Neurotoxicology and Neuroendocrinology, Italian Institute of Health, Rome; Prof. Andrea Mele, Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome. Thesis title: “Ultrasonic vocalizations emitted by mouse pups in response to social isolation: spectrographic differences and effects on mother in two different strains on mice.”

2005-2009 Bachelor Degree in Biology, 100/110 Sapienza, University of Rome. Supervised by Prof. Giancarlo Poiana, Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome. Thesis tytle: “The role of the receptor for Agrin, LRP4 in the formation of neuromuscular junction”.

Projects

Jan 2015/ Aug 2015 VIB Center for the Biology of Disease, KULeuven- Center for Human Genetics, 3000 Leuven, Belgium. Fellowship granted by Sapienza University of Rome, to work in the field of intellectual disability and Fragile X syndrome.

Jun 2014-Sept 2014 Department of Neurosciences and Brain Technologies, Italian Institute of Technology (IIT), Genoa, Italy.Fellowship granted by IIT, to perform the project “Assessment of social communication deficits in Integrin alphaVbeta3 mutant mice”.

Nov 2011-Dec 2014 Section of Neurotoxicology and Neuroendocrinology, Dept. of Cell Biology and Neurosciences, Italian Institute of Health, Rome, Italy. Worked as Ph.D student in the field of behavioral characterization of animal model of neurodevelopmental disorders.

Jan 2010-Oct 2011 Section of Neurotoxicology and Neuroendocrinology, Dept. of Cell Biology and Neurosciences, Italian Institute of Health, Rome, Italy. Worked as Master student in the context of characterization of the communicative role of ultrasonic vocalizations emitted by rodents.

Selected Publications

Galbusera A, De Felice A, Girardi S, Bassetto G, Maschietto M, Nishimori K, Chini B, Papaleo F, Vassanelli S, Gozzi A. Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates. Neuropsychopharmacology. 2017 Jan 18. doi: 10.1038/npp.2016.283. [Epub ahead of print]

De Felice A, Greco A, Calamandrei G, Minghetti L. Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism. J Neuroinflammation. 2016 Jun 14;13(1):149. doi: 10.1186/s12974-016-0617-4.

Venerosi A, Tait S, Stecca L, Chiarotti F, De Felice A, Cometa MF, Volpe MT, Calamandrei G, Ricceri L. Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers. Environmental Health, 2015 Apr 2;14(1):32.

De Felice A, Ricceri L, Venerosi A, Chiarotti F, Calamandrei G. Multifactorial origin of Neurodevelopmental disorders: Approaches to understanding Complex Etiologies. Toxics 2015, 3(1), 89-129; doi:10.3390/toxics3010089.

De Felice A, Scattoni ML, Ricceri L, Calamandrei G. Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism. PLoS One. 2015 Mar 24;10 (3):e0121663. doi: 10.1371/journal.pone.0121663. eCollection 2015.

De Felice A, Venerosi A, Ricceri L, Sabbioni M, Scattoni ML, Calamandrei G. Gestational exposure to the organophosphate insecticide chlorpyrifos alters social investigation in adult female mice Neurotoxicology and Teratology 2014 Nov-Dec;46:32-9. doi: 10.1016/j.ntt.2014.09.002.

Cutuli D, Giorgi MC, De Felice A, Calamandrei G. Maternal care alteration in the BTBR T +tf/J mouse, a murine model of autism. Comparative Medicine, 2013 63(6).

Non-peer reviewed journal

Scattoni ML, Michetti C, De Felice A, Ricceri L. “Modelli animali di autismo: un approccio traslazionale”. 2011. (Rapporti ISTISAN 11/33).

De Felice A. (2014). Il cervello gioca in difesa. Storie di cellule che pensano. (G. Martino). Sapere, Febbraio 2014:54.

Book chapter

De Felice A, Confaloni A, Crestini A, De Simone R, Malchiodi-Albedi F, Martire A, Matteucci A, Minghetti L, Popoli P, Venerosi A, Calamandrei G. Branched chain amino-acids in amyotrophic lateral sclerosis. In Branched chain amino acids in health and disease, Vol. 1, Part III, pp. 229-243; Eds. Rajendram R., Preedy V.R., Patel V.B. 2015, Springer, London (UK).

IIT Publications

  • 2018
  • De Felice A.iit, Pagani M.iit, Galbusera A.iit, Gozzi A.iit

    Acute and Chronic intranasal oxytocin differentially affect brain functional connectivity

    10th FENS Forum of Neuroscience
  • Maddaloni G., Migliarini S., Napolitano F., Giorgi A., Nazzi S., Biasci D., De Felice A.iit, Gritti M., Cavaccini A., Galbusera A.iit, Franceschi S., Lessi F., Ferla M., Aretini P., Mazzanti CM., Tonini R., Gozzi A.iit, Usiello A., Pasqualetti M.
    DOI

    Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress.

    Scientific Reports
  • 2017
  • Galbusera A.iit, De Felice A.iit, Girardi S., Bassetto G., Maschietto M., Nishimori K., Chini B., Papaleo F.iit, Vassanelli S., Gozzi A.iit
    DOI

    Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates

    Neuropsychopharmacology, vol. 42, (no. 7), pp. 1420-1434
  • 2016
  • De Felice A., Greco A., Calamandrei G., Minghetti L.
    DOI

    Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism

    Journal of Neuroinflammation, vol. 13, (no. 1)

Awards

STUDENT SCHOLARSHIPS AND AWARDS

2010: Scholarship to work for one year (from 20/01/2010 to 15/01/2011) at the library of the Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome.

2011: Three years fellowship as Ph.D student for the School in Pharmacology and Toxicology, curriculum Toxicology, Sapienza University of Rome.

2013: Selected as speaker for the “Young Investigator Symposium” at the 7° international Meeting of Steroids and Nervous System, 16-20 February, Turin Italy.

2013: Best Poster Award at International Neurotoxicology Association (INA-14), Egmond aan Zee, Netherlands. 2013: Passed the government exam at Sapienza University of Rome and licensed as a professional biologist of the Italian Biology Society.

2014: Fellowship granted by asSAGGI s.r.l. to realize a project of neuroscience for children named "Che ti passa per la testa? Neuroscienze per i più piccoli", winner of the Experimental School of Scientific Communication (1000€).

2014: Scientific Journalist for European Space Agency (ESA) during the exhibition “My Planet from the Space: Fragility and Beauty”, Palazzo delle Esposizioni, Rome, Italy.

2014: Fellowship granted by Sapienza University of Rome, for an exchange project of eight months at VIB Center for the Biology of Disease KULeuven- Center for Human Genetics, 3000 Leuven.

TRAVEL GRANTS

2012: Travel Grant to attend the Meeting organized by Italian society of Neuroscience (SINS) Catania, Italy.

2013: Travel Grant to participate at the Training Summer School in Neuroendocrinology FENS/IBRO, Prato, Italy. 2014: Travel Grant to attend at the 9th FENS Forum of Neuroscience, Milan Italy.

2015: Travel Grant to attend at the XVI Meeting of Italian Society of Neuroscience, Cagliari Italy.